Acne-induced Post-inflammatory Hyperpigmentation: From Grading to Treatment

Area of Science:

• Dermatology
• Aesthetic Medicine
• Clinical Research

Background:

• Acne-induced post-inflammatory hyperpigmentation (AI-PIH) is a common sequela of acne, often occurring without significant visible inflammation.
• Current assessment of AI-PIH severity relies on subjective visual evaluation, lacking standardized criteria for treatment.
• Epidemiological data are limited, though AI-PIH is more prevalent in individuals with darker skin types (Phototypes IV-VI).

Purpose of the Study:

• To develop an accessible AI-PIH severity grading tool for routine clinical practice.
• To propose evidence-based preventive strategies and a treatment algorithm for AI-PIH.
• To enhance the management of AI-PIH through standardized assessment and patient education.

Main Methods:

• A panel of five acne experts provided insights into AI-PIH epidemiology and pathophysiology.
• Development of the Acne PIgmentation Grading (APG) tool for severity assessment.
• Formulation of preventive measures and a tiered treatment algorithm based on APG severity.

Main Results:

• The Acne PIgmentation Grading (APG) tool offers a straightforward method for assessing AI-PIH severity in clinical settings.
• Preventive recommendations and a structured treatment algorithm are proposed, tailored to AI-PIH severity.
• The study emphasizes the importance of patient education in managing AI-PIH.

Conclusions:

• The developed AI-PIH grading tool and treatment algorithm provide a practical framework for clinicians.
• Standardized assessment and management strategies can improve patient outcomes for AI-PIH.
• Further research into AI-PIH pathophysiology and epidemiology is warranted.