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Phaeoacremonium iranianum - a new corneal pathogen
Xiaona Liu1, Xiuhai Lu2, Juanjuan Zheng1
1Clinical Laboratory, Jinan Mingshui Eye Hospital, Longquan Road 5601, Zhangqiu District, Jinan, China.
BMC Ophthalmology
|April 23, 2025
Summary
Phaeoacremonium iranianum caused a rare corneal infection. Prompt antifungal therapy and keratectomy successfully controlled the infection, offering insights into managing this fungal keratitis.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Phaeoacremonium species are environmental fungi, typically causing plant diseases.
- Human infections by Phaeoacremonium are uncommon.
Purpose of the Study:
- To report a rare case of corneal infection caused by Phaeoacremonium iranianum.
- To contribute to the clinical understanding and management of Phaeoacremonium-induced fungal keratitis.
Main Methods:
- A patient presented with a corneal ulcer due to Phaeoacremonium iranianum.
- Antifungal susceptibility testing was performed.
- Treatment involved aggressive antifungal therapy and keratectomy.
Main Results:
- Antifungal susceptibility testing showed voriconazole (0.5 µg/ml) and amphotericin B (0.05 µg/ml) were highly effective.
- The patient underwent keratectomy combined with antifungal therapy.
- One month post-treatment, the corneal infection was controlled with residual opacity.
Conclusions:
- This case highlights Phaeoacremonium iranianum as a potential cause of fungal keratitis.
- Successful management involved a combination of surgical intervention and targeted antifungal treatment.
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