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Updated: May 10, 2025
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
Published on: May 6, 2020
L-shaped association of bone mineral density with all-cause mortality in individuals with osteoarthritis
Yixuan He1,2, Juan Sun1, Jie Li3
1Department of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background:
Osteoarthritis (OA) is a common joint disease that poses a significant public health burden, particularly in older adults. Despite research on its impact, the role of bone mineral density (BMD) in OA prognosis remains underexplored. This study investigates the association between BMD, measured using dual-energy X-ray absorptiometry (DXA), and all-cause mortality in individuals with OA using data from the National Health and Nutrition Examination Survey (NHANES).
Methods:
This retrospective cohort study utilized NHANES data from 1999 to 2018, including participants aged 20 years and older (n = 55,081). After excluding individuals with missing BMD or mortality data, 1,573 participants diagnosed with OA were analyzed.
Results:
The multivariate-adjusted hazard ratio (HR) for BMD and all-cause mortality was 0.344 (0.153, 0.774), indicating a protective effect of higher BMD. We observed an L-shaped relationship between BMD and mortality: a 1-unit decrease in BMD was associated with a 97.3% increased HR for mortality when BMD was below 1.216 g/cm² (HR 0.027, 95% CI 0.010-0.069). No significant association was found for higher BMD levels (HR 4.490, 95% CI 0.431-46.754). In age-stratified analysis, a significant association was found in both those under and over 50 years old.
Conclusions:
This study reveals an L-shaped association between BMD and all-cause mortality in individuals aged 20 and older with OA, underscoring the importance of maintaining bone health in this population. These findings highlight BMD as a prognostic marker and suggest that monitoring BMD could improve clinical outcomes for OA patients.
Clinical Trial Number:
Not applicable.
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