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The Adverse Influence of Maternal Glycaemia During Pregnancy on Offspring's Cardiometabolic Health Profiles

Wen Lun Yuan1,2, Aminata H Cissé1, Muriel Tafflet1

  • 1Université Paris Cité and Université Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France.

Acta Paediatrica (Oslo, Norway : 1992)
|April 23, 2025
PubMed

Insights

Children’s cardiometabolic health profiles at age 5-6 years are linked to earlier adiposity rebound. Maternal hyperglycemia during pregnancy showed marginal associations with these health profiles in offspring.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Health
  • Metabolic Health

Background:

  • Cardiometabolic health in early childhood is crucial for long-term well-being.
  • Adiposity rebound (AR) timing is an indicator of future metabolic risk.
  • Maternal hyperglycemia during pregnancy may impact offspring's metabolic development.

Purpose of the Study:

  • To characterize cardiometabolic health profiles in 5-6-year-old children.
  • To examine the correlation between these profiles and the age at adiposity rebound.
  • To investigate associations with maternal hyperglycemia during pregnancy.

Main Methods:

  • Utilized data from the French EDEN birth cohort study.
  • Assessed BMI, fat mass, blood pressure, fasting plasma glucose (FPG), HOMA-IR, and lipids in children.
  • Employed principal component analysis for profile derivation and multiple linear regressions for association analyses.

Main Results:

  • Identified four sex-specific cardiometabolic profiles, including 'higher adiposity, BP, IR'.
  • The 'higher adiposity, BP, IR' profile correlated with an earlier age at adiposity rebound in both sexes.
  • Higher maternal FPG was associated with 'higher adiposity, BP, IR' in boys and dyslipidemia in girls.

Conclusions:

  • A 'higher adiposity, BP, IR' profile at age 5-6 years is associated with an earlier adiposity rebound.
  • Maternal hyperglycemia during pregnancy demonstrated marginal associations with offspring's cardiometabolic health profiles.
Abstract

Keywords:
adiposity reboundcardiometabolic healthchildrengestational diabetes mellitusgestational glycaemia

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