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Updated: May 10, 2025
04:01
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
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Pro-inflammatory Cytokines, Ferroptosis, and Cancer
A A Vartanian1, V S Kosorukov1
1N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia, Moscow, 115478 Russian Federation.
Acta Naturae
|April 23, 2025
Summary
Ferroptosis, a cell death pathway, is linked to cancer therapy resistance. Chronic inflammation and pro-inflammatory cytokines contribute to this resistance by affecting the tumor microenvironment.
Area of Science:
- Oncology
- Cell Biology
- Immunology
Background:
- Ferroptosis is an iron-dependent regulated cell death.
- It is triggered by lipid peroxidation and regulated by glutathione peroxidase 4.
- Ferroptosis resistance is increasingly linked to resistance against various cancer therapies.
Purpose of the Study:
- To review the fundamental principles of ferroptosis in cancer.
- To explore the connection between ferroptosis and cancer therapy resistance.
- To highlight the role of the tumor microenvironment and inflammation in ferroptosis resistance.
Main Methods:
- Literature review of ferroptosis and cancer therapy resistance.
- Analysis of the mechanisms underlying ferroptosis.
- Examination of the tumor microenvironment's role in ferroptosis resistance.
Main Results:
- Ferroptosis resistance is associated with chemo-, radio-, immuno-, and targeted therapy resistance.
- An immunosuppressive tumor microenvironment is a significant factor in ferroptosis resistance.
- Excessive, chronic production of pro-inflammatory cytokines promotes ferroptosis resistance in tumors.
Conclusions:
- Understanding ferroptosis is crucial for overcoming cancer therapy resistance.
- Targeting ferroptosis pathways may offer new therapeutic strategies.
- Modulating the tumor microenvironment and inflammatory responses is key to enhancing cancer treatment efficacy.
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