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Related Experiment Video

Updated: May 10, 2025

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
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Collapsing Focal Segmental Glomerulosclerosis With Concurrent IgG4 Nephropathy.

Eugene K Yeboah1, Surya V Seshan2, Fnu Pariya3

  • 1Internal Medicine, State University of New York Downstate Medical Center, Brooklyn, USA.

Cureus
|April 23, 2025
PubMed
Summary

This case report details a rare dual diagnosis of IgG4-related kidney disease and APOL1-associated collapsing glomerulopathy in a patient with chronic kidney disease. Treatment with steroids and mycophenolate mofetil stabilized kidney function and normalized IgG4 levels.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology
Keywords:
1 collapsing fsgs superimposed with igg4apol1 genecollapsing fsgsigg4 diseaseigg4 nephropathyigg4 related tubulointerstitial nephritisigg4-related kidney disease

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Background:

  • A 41-year-old male with existing chronic kidney disease, hypertension, and psoriasis presented with worsening kidney function and nephrotic range proteinuria.
  • Initial investigations revealed elevated inflammatory markers (ESR, CRP), positive anti-dsDNA antibodies, and elevated IgG subsets (2, 3, 4), alongside a high-risk APOL1 variant.
  • Normal complement levels and negative ANA/anti-beta-glycoprotein-1 antibodies guided further diagnostic considerations.