Age-specific gender differences in morphological parameters of intracranial aneurysms

Area of Science:

• Neurology
• Radiology
• Medical Imaging

Background:

• Gender disparities are recognized in subarachnoid hemorrhage and intracranial aneurysm (IA) development.
• Limited research has explored gender-specific variations in IA morphology.

Purpose of the Study:

• To investigate gender differences in the morphological characteristics of intracranial aneurysms.
• To determine if age influences these gender-based morphological variations.

Main Methods:

• Retrospective analysis of 346 intracranial aneurysms in 308 patients (2014-2020).
• Comparison of 10 morphological parameters between male and female patients.
• Subgroup analysis based on age: ≥60, 50-59, and <50 years.

Main Results:

• Males showed significantly higher aspect ratio maximum, aspect ratio, bottleneck factor, and volume-to-ostium area ratio compared to females (P < 0.01).
• These morphological differences were most pronounced in patients aged ≥60 years.
• No significant gender differences were observed in patients <50 years.

Conclusions:

• Intracranial aneurysm morphology exhibits gender differences that are influenced by age.
• The most significant morphological variations between genders were observed in older adults (≥60 years).
• Age is a critical factor in understanding gender-specific intracranial aneurysm morphology.