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How Does the Mandible Age? Comprehensive Artificial Intelligence-Assisted Shape Analysis in the White Population
Sara M Hussein1,2, Jess D Rames1, Abdallah A Shehab1
1From the Division of Plastic and Reconstructive Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.
Plastic and Reconstructive Surgery. Global Open
|April 23, 2025
Summary
Facial bone aging shows distinct patterns in men and women. Mandible width increases with age, while height decreases, with sex-specific bone resorption differences observed.
Area of Science:
- Anatomy
- Anthropology
- Biomedical Engineering
Background:
- Mandibular contour is crucial for facial aesthetics and rejuvenation.
- Limited research exists on facial aging patterns across different age groups and sexes.
- Understanding mandibular aging is key for effective aesthetic and reconstructive procedures.
Purpose of the Study:
- To investigate sex-specific mandibular aging patterns using advanced 3D analysis.
- To identify age-related changes in mandibular morphology.
- To apply artificial intelligence and statistical shape modeling to visualize population-level aging trends.
Main Methods:
- Retrospective analysis of 280 White patients' facial computed tomography scans.
- Stratification into three age groups (20-79 years) and by sex.
- AI-assisted 3D mandible segmentation and statistical shape modeling for comparative analysis.
Main Results:
- Significant age-related changes in mandible morphology observed in both sexes.
- Ramus height decreased with age (approx. 5.3 mm in women, 4.2 mm in men).
- Interrami and intercondylar widths increased; women showed increased mandibular angle and chin resorption, while men had gonion projection resorption.
Conclusions:
- Mandibular aging exhibits sex-specific bone remodeling patterns, independent of tooth loss.
- Posterior mandibular width increases, and ramus height decreases with age.
- Women experience greater anterior alveolar and chin resorption than men, highlighting sex-dimorphic aging.
