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Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

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Emerging Treatments for Persistent Corneal Epithelial Defects.

Jeonghyun Esther Kwon¹, Christie Kang², Amirhossein Moghtader¹

¹Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.

Vision (Basel, Switzerland)

|April 23, 2025

Summary

Persistent corneal epithelial defects (PCEDs) hinder healing. Novel stem cell and regenerative therapies show promise for improving corneal repair and patient outcomes.

Keywords:

Cornea Corneal Neurotization Limbal Cell Reconstruction Limbal Stem Cell Deficiency Neurotrophic Keratitis Ocular Surface Persistent Corneal Epithelial Defect Persistent Epithelial Defect

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Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

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Published on: February 15, 2019

Area of Science:

Ophthalmology
Regenerative Medicine
Cell Biology

Background:

Persistent corneal epithelial defects (PCEDs) are difficult to treat, with standard care often failing to promote timely corneal healing.
Current treatments primarily offer lubrication and mechanical support, lacking targeted therapeutic action for re-epithelialization.

Purpose of the Study:

To review current management strategies for PCEDs.
To highlight emerging non-surgical and surgical treatments for enhancing corneal healing.

Main Methods:

Literature review of current and novel therapeutic approaches for PCEDs.
Analysis of regenerative medicine principles applied to corneal wound healing.

Main Results:

Novel non-surgical treatments utilize growth factors and cell-based therapies, including mesenchymal stem cells, platelets, and specific peptides.
Emerging surgical options involve corneal neurotization and limbal stem cell reconstruction using advanced biomaterials and cell sources.

Conclusions:

Innovative treatments harnessing regenerative medicine hold significant potential for advancing PCED management.
Future therapies aim to improve corneal re-epithelialization efficiency and clinical outcomes for patients with persistent defects.