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Updated: May 23, 2025

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Published on: May 5, 2014
Advancing curation of viral life cycles, host interactions, and therapeutics in Reactome
Lisa Matthews1, Justin Cook2, Ralf Stephan3,4
1Department of Biochemistry and Molecular Pharmacology, NYU Langone Health Center, New York, New York, USA.
Abstract:
Reactome (reactome.org) is a manually curated, peer-reviewed, open-source, open-access pathway knowledgebase of essential human cellular functions. Reactome includes viral life cycles that capture a broad range of virus-induced human pathology. Here, we describe a workflow using collaborative curation strategies, orthoinference procedures, and literature triage to rapidly create reliable molecular models of emergent viruses. The resulting pathway data set rigorously details viral infection pathways, interactions with normal human biological processes, and potential therapeutic compounds.
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