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Updated: May 10, 2025
MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
Published on: December 13, 2017
Cognitive Outcomes Following Second-Sided Focused Ultrasound Thalamotomy for Tremor
Silina Z Boshmaf1, Julie Petersen2,3, Rohina Kumar1
1Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Background:
Historically, staged bilateral thalamotomy has been associated with cognitive decline.
Objective:
To examine cognitive outcomes of second-sided focused ultrasound (FUS) thalamotomy in individuals with medication-refractory essential tremor (ET) who previously underwent unilateral FUS thalamotomy.
Methods:
Twenty-one individuals with medication-refractory ET completed cognitive testing before undergoing second-sided FUS thalamotomy and 4 months post-FUS. Cognitive changes were analyzed at the group and individual levels.
Results:
At the group level, no significant declines were observed on any of the test scores. At the individual level, most cognitive test scores remained stable (95% of scores), with declines (2% of scores) and improvements (3% of scores) occurring infrequently. Specifically, declines were observed on only four of the 19 cognitive test scores. No more than two participants declined on any single test score and no participant declined on more than two cognitive test scores.
Conclusions:
Second-sided FUS thalamotomy is associated with minimal risk of cognitive decline.
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