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Updated: May 10, 2025

Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

69.9K

NOX Family: Regulators of Reactive Oxygen Species Balance in Tumor Cells

Bin Xiong1,2, Yang Zhang2, Siyi Liu2

  • 1Department of Radiation Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Changsha, Hunan, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|April 23, 2025
PubMed

Insights

NADPH oxidases (NOX) are crucial for cancer cell survival in low-oxygen (hypoxic) environments. Targeting NOX enzymes offers a promising strategy for novel cancer therapies by disrupting tumor growth and spread.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cancer cells adapt to hypoxic conditions via complex mechanisms.
  • Reactive oxygen species (ROS) production, mainly from NADPH oxidases (NOX), is elevated in cancer.
  • Tumor cells counteract oxidative stress by increasing antioxidant synthesis.

Purpose of the Study:

  • To review the characteristics of NOX family members in cancer.
  • To explore NOX's role in tumor proliferation, invasion, migration, and angiogenesis.
  • To examine NOX's impact on the tumor immune microenvironment and its therapeutic potential.

Main Methods:

  • Literature review of NOX family members' functions in malignancies.
  • Analysis of NOX involvement in redox-dependent signaling pathways.
  • Synthesis of current understanding on targeting NOX for cancer treatment.

Main Results:

  • NOX enzymes are altered in various cancers, influencing key oncogenic processes.
  • NOX family members play significant roles in tumor growth, metastasis, and angiogenesis.
  • NOX activity impacts immune cell function within the tumor microenvironment.

Conclusions:

  • NOX family members are critical regulators of cancer cell adaptation and progression.
  • Targeting NOX presents a viable therapeutic strategy for multiple cancer types.
  • Further research into NOX functions can provide new insights into cancer biology and treatment.
Keywords:
NADPH oxidaseROStherapytumor angiogenesistumor microenvironment

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