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Targeted Delivery of Personalized Cancer Vaccines Based on Antibody-Antigen Complexes

Yaling Zhang1, Lingling Yan1, He Sun1

  • 1School of Life Sciences, Shanghai University, Shanghai 200444, China.

Vaccines
|April 23, 2025
PubMed
Abstract

Insights

This study developed a novel personalized cancer vaccine using antibody-antigen complexes for improved antigen-presenting cell (APC) delivery. This approach enhances T-cell responses and antitumor effects in preclinical models.

Area of Science:

  • Immunology
  • Cancer Research
  • Vaccine Development

Background:

  • Personalized cancer vaccines targeting tumor neoantigens offer high safety and specificity.
  • Efficient delivery of these vaccines to antigen-presenting cells (APCs) remains a significant challenge.

Purpose of the Study:

  • To develop and evaluate a personalized cancer vaccine strategy using antibody-antigen complexes.
  • To enhance the utilization of tumor neoantigens by APCs for improved antitumor immunity.

Main Methods:

  • Mice were immunized with keyhole limpet hemocyanin (KLH) to generate anti-KLH antibodies.
  • Mice received a personalized vaccine comprising KLH-loaded tumor neoantigens and CpG ODN.
  • Immunological and antitumor effects were assessed.

Main Results:

  • Pre-immunization with KLH enhanced the uptake of the KLH-based vaccine by dendritic cells (DCs) and macrophages (Mφs).
  • This enhanced uptake strengthened T-cell immune responses against tumors.
  • The strategy demonstrated improved immune activation and antitumor potential.

Conclusions:

  • This study presents a novel approach for targeted delivery of personalized cancer vaccines.
  • Antibody-antigen complex formation shows promise for enhancing vaccine efficacy.
Keywords:
antibody–antigen complexescancer vaccineimmunotherapyneoantigen

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