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Not all colon cancer patients with preoperative hyperinflammatory status are at high risk of muscle loss and poor prognosis

  • 0Department of Geriatrics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
International Journal of Colorectal Disease +

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April 23, 2025

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April 23, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Persistent postoperative inflammation, not preoperative, increases colon cancer patients' risk of muscle wasting and poor prognosis. Targeting this inflammation may improve survival and reduce muscle loss.

Area Of Science

  • Oncology
  • Immunology
  • Nutrition

Background

  • Preoperative inflammation is linked to poor outcomes in colon cancer patients.
  • The role of fluctuating inflammation post-surgery on muscle wasting is unclear.

Purpose Of The Study

  • To investigate the impact of different inflammatory trajectories on muscle wasting in colon cancer patients.
  • To identify risk factors for postoperative sarcopenia and their effect on prognosis.

Main Methods

  • Retrospective study of 193 stage II/III colon cancer patients (2015-2021).
  • Assessed inflammation using neutrophil-to-lymphocyte ratio (NLR) and prognostic immunological and nutritional index (PINI) pre- and post-operatively.
  • Categorized patients into four inflammation trajectory groups (low-low, high-low, low-high, high-high).
  • Analyzed associations with postoperative sarcopenia, skeletal muscle index (SMI%), density loss rate (SMD%), overall survival (OS), and recurrence-free survival (RFS).

Main Results

  • Consistently high postoperative inflammation (G4) significantly increased skeletal muscle index (SMI%) and density loss rate (SMD%) compared to consistently low inflammation (G1).
  • Elevated inflammation was an independent risk factor for postoperative sarcopenia.
  • Postoperative sarcopenia and high PINI in G4 independently influenced OS and RFS.

Conclusions

  • Persistent postoperative inflammation, rather than preoperative inflammation alone, is associated with increased muscle wasting and poor prognosis in colon cancer.
  • Modulating postoperative inflammation presents a potential therapeutic strategy to mitigate muscle loss and improve survival.
  • Findings support the development of targeted anti-inflammatory therapies for specific patient populations.

Keywords:

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