A review on plant-mediated synthesis of AgNPs and their formulations for wound healing application

Wound healing is a sophisticated and dynamic process carried out by a myriad of cellular activities that work together in a coordinated manner to effectively repair damaged tissue. It involves a cascade process involving hemostasis, inflammation, granulation, maturation, and remodeling. However, in the case of chronic wounds, owing to the delayed wound healing process, various microbes invade the wound area and produce biofilms that hinder the healing process. Owing to rapid advancements in nanotechnology, several nanomaterials with diverse formulations have been investigated for wound healing. Among them, silver nanoparticles (AgNPs) have shown excellent properties, as they have unique physiochemical properties that address the problems associated with wound healing. The antibacterial and antioxidant properties of silver greatly enhance wound-care diagnostics. The use of medicinal plants for green synthesis of AgNPs has been widely researched, with these plants serving as both reducing and stabilizing agents in the nanoparticle formation process. This review focuses on different wound types, problems related to wounds, green-synthesized AgNPs using medicinal plants, and their limitations and advantages in wound dressing formulations. This study aims to provide the scientific community with a directional view in analyzing the role and importance of green-synthesized AgNPs in wound care.