Amphiphilic Glycoprobes for Cell Surface Engineering and Drug Delivery

Amphiphilic glycopeptides and glycopolymers have been characterized as potential glycocalyx engineering probes to regulate growth factors mediated stem cell differentiation and neural plasticity. Here, we describe a rational and facile method to synthesize fluorescent tagged amphiphilic multivalent glycoprobes using solid-phase peptide synthesizer and copper-free click chemistry. As a prototype, we report the synthesis of fluorescently tagged penta-valent sulfated L-iduronic acid glycopeptide for cell surface engineering and imaging.