Related Experiment Video
Updated: May 10, 2025

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
Published on: October 6, 2023
Poor sleep and high rheumatoid arthritis risk: Evidence from large UK Biobank cohort
Yi-Qun Yang1,2, Han-Wen Cao1,2, Xing-Hao Yu3
1Collaborative Innovation Center for Bone and Immunology between Sihong Hospital and Soochow University; Center for Genetic Epidemiology and Genomics, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, P. R. China.
Objective:
To evaluate the relationship between sleep behaviors and rheumatoid arthritis (RA) risk.
Methods:
First, based on large-scale data from the UK Biobank, we analyzed the associations between multiple sleep factors and RA risk and calculated a poor sleep score (PSS) to assess their combined effect. Then we constructed genetic risk scores (GRS) based on a large genome-wide association study and assessed the interaction or combined effect of sleep and genetic factors on RA risk. Finally, we conducted a case-control study to explore the effect of RA on sleep.
Results:
Sleep duration, getting up, napping during the day, insomnia, and daytime dozing were associated with the risk of RA, but no associations were observed for chronotype and snoring with RA. Participants in the high genetic risk and high PSS group had a 363.1% higher risk of developing RA compared to those with low genetic risk and low PSS. We also found that women were more likely than men to be affected by the combined effects of PSS and GRS. In the case-control study, there were statistically significant associations of RA with getting up, PSS grade and PSS.
Conclusions:
Unhealthy sleep patterns were associated with increasing risk of RA among participants with low, intermediate, or high genetic risk.
More Related Videos
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
REM Sleep Behavior Disorder
RBD is significantly associated with...
Circadian Rhythms and Gene Regulation
The JAK-STAT Signaling Pathway
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...

