The diagnostic performance and reader agreement of the Prostate Imaging for Recurrence Reporting system in the evaluation of local recurrence in patients with biochemically recurrent prostate cancer
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View abstract on PubMed
Summary
This summary is machine-generated.The Prostate Imaging for Recurrence Reporting (PI-RR) system shows good accuracy and agreement for detecting local recurrence in prostate cancer patients after radiation therapy or surgery. This system may offer an alternative diagnostic tool for post-treatment prostate cancer monitoring.
Area Of Science
- Radiology
- Oncology
- Medical Imaging
Background
- The Prostate Imaging for Recurrence Reporting (PI-RR) system is a proposed method using multiparametric magnetic resonance imaging (mpMRI) to assess local recurrence in prostate cancer (PCa) patients post-treatment.
- Evaluating local recurrence is crucial for patients who have undergone radiation therapy (RT) or radical prostatectomy (RP).
Purpose Of The Study
- To assess the diagnostic performance of the PI-RR system in identifying locally recurrent PCa.
- To evaluate the interreader agreement among radiologists using the PI-RR system for PCa recurrence diagnosis.
Main Methods
- A retrospective study included 110 patients with biochemically recurrent PCa after RT (n=35) or RP (n=75).
- All patients underwent mpMRI, PSMA-PET/CT, and biopsy; PI-RR was independently assessed by four radiologists.
- Biopsy pathology served as the reference standard; ROC curves and ICC were used for performance and agreement analysis.
Main Results
- Of 110 patients, 28 had local recurrence. PI-RR showed areas under the ROC curve (AUC) ranging from 0.61-0.84 (RT) and 0.71-0.89 (RP) with a cutoff of 4.
- The intraclass correlation coefficient (ICC) for interreader agreement was 0.86 (95% CI: 0.81-0.91).
Conclusions
- The PI-RR system, with a cutoff of 4, demonstrates favorable diagnostic performance and interreader agreement for detecting local recurrence.
- PI-RR may serve as a valuable alternative tool for identifying local recurrence in biochemically recurrent PCa patients treated with RT or RP.
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