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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

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RETINAL TOXICITY ASSOCIATED WITH NAB-PACLITAXEL AND GEMCITABINE WITH SBP-101.

Ashley Z Zhou¹, Jin Kyun Oh², Stephen H Tsang²

¹Columbia University Vagelos College of Physicians and Surgeons, New York, New York.

Retinal Cases & Brief Reports

|April 23, 2025

Summary

This case report identifies retinal toxicity in patients receiving nab-paclitaxel and gemcitabine with SBP-101 for pancreatic cancer. The study observed pigmentary changes and RPE mottling, emphasizing the need for ophthalmology monitoring.

Keywords:

SBP-101 gemcitabine nab-paclitaxel retinal toxicity

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Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

Area of Science:

Ophthalmology
Oncology
Pharmacology

Background:

Metastatic pancreatic adenocarcinoma treatment often involves combination chemotherapy.
Nab-paclitaxel and gemcitabine are standard chemotherapeutic agents.
SBP-101 is an investigational polyamine inhibitor used in combination therapy.

Purpose of the Study:

To document and characterize retinal toxicity associated with nab-paclitaxel and gemcitabine in combination with SBP-101.
To investigate the ocular side effects of this specific chemotherapeutic regimen.

Main Methods:

Observational case report design.
Detailed ophthalmological examinations including spectral domain optical coherence tomography (OCT).
Monitoring of visual acuity and retinal findings over time.

Main Results:

Two patients with metastatic pancreatic ductal adenocarcinoma exhibited retinal pigmentary changes and retinal pigment epithelium (RPE) mottling.
OCT revealed RPE and outer retinal speckled reflectivity in the macula.
Retinal findings progressed despite drug discontinuation, with stable or slightly worsened visual acuity.

Conclusions:

Nab-paclitaxel and gemcitabine with SBP-101 demonstrated retinal toxicity in these cases.
Regular ophthalmology examinations are crucial for patients undergoing this treatment.
Further research is warranted to understand the mechanism and long-term implications of this ocular toxicity.