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Updated: Jun 12, 2025

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
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PROSTACYCLIN-ANALOG THERAPY FOR PULMONARY VASCULAR DYSFUNCTION DURING SEVERE ACUTE CHEST SYNDROME IN SICKLE CELL

Julien Lopinto, Elsa Moncomble, Ségolène Gendreau

    Shock (Augusta, Ga.)
    |April 23, 2025
    PubMed
    Summary

    Parenteral epoprostenol significantly reduced pulmonary artery systolic pressure in sickle cell patients with acute chest syndrome-related acute cor pulmonale. This therapy offers a promising treatment for this critical condition.

    Keywords:
    ACP — acute core pulmonaleACS — acute chest syndromeARDS — acute respiratory distress syndromeDHTR — delayed hemolytic transfusion reactionEDEI — end-diastolic eccentricity indexESEI — end-systolic eccentricity indexICU — intensive care unitIQR — interquartile rangePASP — pulmonary artery systolic pressurePGI2 — prostacyclinSAPS II — Simplified Acute Physiology Score IISCD — sickle cell diseaseSD — standard deviationSickle cell diseaseTAPSE — tricuspid annular plane systolic excursionTRV — tricuspid regurgitant jet velocityVOC — vaso-occlusive crisisacute chest syndrome, acute cor pulmonaleepoprostenoliNO — inhaled nitric oxidepulmonary vascular dysfunction

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