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  1. Home
  3. Multicenter Study On Caregiver Experiences In Pediatric Hematopoietic Stem Cell Transplantation Part I: Integrative Analysis Of Mental Health, Psychosocial Stressors, And Support Mechanisms.
  1. Home
  3. Multicenter Study On Caregiver Experiences In Pediatric Hematopoietic Stem Cell Transplantation Part I: Integrative Analysis Of Mental Health, Psychosocial Stressors, And Support Mechanisms.

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Multicenter Study on Caregiver Experiences in Pediatric Hematopoietic Stem Cell Transplantation Part I: Integrative

Neel S Bhatt1, Leslie Lehmann2, Christopher E Dandoy3

  • 1Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.

Transplantation and Cellular Therapy
|April 23, 2025

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
Caregiver burdenFinancial challengesMental healthPediatric hematopoietic stem cell transplantPsychosocial stressQualitative longitudinal researchResilienceSupport mechanisms

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Caregivers for children undergoing hematopoietic stem cell transplantation (HSCT) experience significant stress. Enhanced support and resources are crucial for improving caregiver well-being and patient outcomes.

Area of Science:

  • Pediatric Hematology/Oncology
  • Psychosocial Oncology
  • Qualitative Health Research

Background:

  • Caregivers of children undergoing allogeneic hematopoietic stem cell transplantation (HSCT) face multifaceted challenges.
  • These challenges encompass psychological distress, social disruption, and logistical burdens throughout the transplant journey.

Purpose of the Study:

  • To explore the evolving mental health experiences, stressors, and coping mechanisms of caregivers during pediatric HSCT.
  • To identify key factors influencing caregiver well-being and resilience across different phases of transplantation.

Main Methods:

  • A multicenter, longitudinal qualitative study involving 49 caregivers of children undergoing HSCT.
  • Interviews were conducted at four critical time points: transplant day (d 0), and at 30, 100, and 180 days post-transplant.

Main Results:

  • Caregivers reported acute distress early on, driven by hospital restrictions, intense caregiving demands, financial strain, and family separation.
  • Challenges evolved to include home care navigation, managing uncertainty, and balancing family needs, with persistent anxiety about relapse and complications.
  • Resilience was fostered by children's strength, open communication, healthcare support, financial aid, and mental health services.

Conclusions:

  • Caregivers require enhanced inpatient environments, clearer outpatient guidance, structured mental health support, and practical resources like handbooks.
  • Holistic, family-centered care addressing psychosocial and practical needs is vital.
  • Tailored, time-sensitive support strategies are essential for caregiver well-being and optimizing patient outcomes in pediatric HSCT.