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Published on: June 8, 2016
Antithrombotic macrocyclic sesquiterpene pyridine alkaloids from Tripterygium hypoglaucum
Qiong Jin1, Jia-Shan Shen2, Xian-Run Wu3
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China; Yunnan Yunzhong Institute of Nutrition and Health, Yunnan University of Chinese Medicine, Kunming, 650500, China.
Abstract:
Six previously undescribed macrocyclic sesquiterpene pyridine alkaloids (SPAs) derivatives, named triptocumines A-F (1-6), as well as eighteen known analogs, were isolated from Tripterygium hypoglaucum. The structures were assigned based on analysis of spectroscopic data and electron circular dichroism calculations. Furthermore, compounds 1-6, 8, and 24 could effectively inhibit adenosine diphosphate-induced platelet aggregation, alleviate thrombosis and oxidative stress in zebrafish, reduce endothelin-1 level, protect endothelial cells from oxidative damage, and promote the formation of lumen structure.
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