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Related Experiment Video

Updated: Jul 10, 2026

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

Touching the invisible: exploring intracellular host-pathogen interactions through multisensory art.

Rachel Elizabeth Jackson¹, Georgia Miller², Rachel Weild³

¹Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

Immunology and Cell Biology

|April 23, 2025

Summary

This study created a 3D model of a mammalian cell to explain how intracellular bacteria like Salmonella, Chlamydia, and Orientia survive and replicate inside host cells. The tactile display made complex bacterial science accessible to the public.

Keywords:

Chlamydia Orientia tsutsugamushi Salmonella intracellular bacteria multisensory science science communication

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Published on: November 18, 2022

Area of Science:

Microbiology
Cell Biology
Science Communication

Background:

Intracellular bacteria, including Salmonella enterica, Chlamydia trachomatis, and Orientia tsutsugamushi, possess complex mechanisms to evade host defenses and replicate within eukaryotic cells.
Communicating the intricate life cycles and survival strategies of these pathogens to a non-scientific audience presents a significant challenge.

Purpose of the Study:

To develop an engaging and accessible method for public outreach on the topic of intracellular bacterial pathogens.
To translate complex scientific concepts of bacterial-host interactions into an understandable format for a general audience, including those with visual impairments.

Main Methods:

A 3D tactile model of a mammalian cell was designed and utilized in a science exhibition setting.
The model incorporated representations of key intracellular bacteria and illustrated critical stages of their life cycles, such as host cell entry and replication.

Main Results:

The tactile display successfully demonstrated bacterial hijacking of host cell machinery, Salmonella type three secretion system (T3SS) protein secretion, Orientia tsutsugamushi microtubule trafficking, and Chlamydia trachomatis replication.
Participant engagement and understanding of intracellular bacterial mechanisms were enhanced through this multisensory approach.

Conclusions:

Multisensory and tactile models are effective tools for science communication, making complex microbiology concepts accessible to diverse public audiences.
This approach successfully conveyed the survival strategies of intracellular bacteria and offered an inclusive experience for low-vision and blind communities.