Particulate Matter Exposure and Viral Infections: Relevance to Highly Polluted Settings such as Ulaanbaatar, Mongolia

Particulate matter (PM), a ubiquitous significant component of the ambient air pollution mixture, significantly contributes to increased global risk for chronic cardiopulmonary diseases, acute hospitalizations, and deaths. One of the causes of this increased risk is because PM exposure increases the incidence and severity of respiratory infections. The respiratory system is particularly vulnerable to air pollution and its impact on infection as it is a key site for exposure both to inhaled pollutants and infectious microbes or viruses. This review examines the current understanding of how PM affects antiviral host defense responses and possible underlying mechanisms.

While numerous studies have associated adverse health outcomes with combined or sequential exposure to inhaled pollutants and viruses, defining causal relationships and mechanisms remains limited. Particularly limited, are contemporary data focuses on low- and middle-income countries, including heavily polluted regions such as Ulaanbaatar, Mongolia. This manuscript focuses on how (1) PM, serving as a carrier for viruses, enhances the transmission of viruses; (2) PM impairs immune defense to viruses; and (3) PM impacts epithelial cell functions to exacerbate viral infections. Given the significant public health hazards on PM, particularly in heavily polluted regions such as Southeast Asia, Middle East and Africa, it is critical to define specific mechanisms of PM on respiratory infection and how their impact may differ in these highly polluted regions. Ultimately, this could devise future public health measures and interventions to limit this substantial public health risk.