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Aberrant aging-associated p62 autophagic cascade in biopsied olfactory neuronal cells from patients with psychosis
Kun Yang1, Koko Ishizuka1, Toshifumi Tomoda2
1Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Abstract:
Sequestosome-1/p62, a key mediator in the clearance of damaged organelles and macromolecules during autophagy, serves as a marker of biological aging. We demonstrate elevated p62 in biopsied neuronal cells in patients with psychosis compared to healthy controls. In healthy controls, p62-indicated biological/autophagic age is positively correlated with chronological age over time, whereas in patients, neuronal p62-indicated biological/autophagic age shows no correlation with chronological age, being significantly higher than chronological age from the onset of the disease.
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