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Updated: May 10, 2025

Single Cell Durotaxis Assay for Assessing Mechanical Control of Cellular Movement and Related Signaling Events
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Single Cell Durotaxis Assay for Assessing Mechanical Control of Cellular Movement and Related Signaling Events

Published on: August 27, 2019

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Frictiotaxis underlies focal adhesion-independent durotaxis

Adam Shellard1, Kai Weißenbruch1, Peter A E Hampshire2,3

  • 1Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.

Nature Communications
|April 23, 2025
PubMed
Summary

Cells can move towards stiffer substrates without focal adhesions, a process newly termed frictiotaxis. This adhesion-independent durotaxis relies on friction, not just stiffness, offering new insights into cell migration.

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