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Updated: Apr 14, 2026

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Recent Advances in Synthesis of the Polycyclic Norcembranoid and Cembranoid Diterpenoids
Peng Chen1, Ruoqi Li1, Ming Zou1
1Henan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology (CAIST), Henan University of Technology, Zhengzhou, 450001, China.
Abstract:
The C19 norcembranoid and C20 cembranoid diterpenoids represent an intriguing class of natural products found in both marine and terrestrial environments. These complexes, with a highly oxygenated state and compact polycyclic structures, have captured the synthetic interests due to their unique bioactivities. Over the past two decades, the total synthesis of these natural products has been a challenging task, driven by their intricate structural features. This review systematically summarizes the recent advances in the total synthesis of various norcembranoid and cembranoid diterpenoids, focusing on their transformations and the latest breakthroughs in this field.
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