Circulating bile acid profiles characteristics and the potential predictive role in clear cell renal cell carcinoma progression
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View abstract on PubMed
Summary
This summary is machine-generated.Altered serum bile acid (BA) profiles are linked to clear cell renal cell carcinoma (ccRCC). Deoxycholic acid (DCA) correlates with ccRCC stage and grade, while CDCA and LCA show biomarker potential.
Area Of Science
- Oncology
- Metabolomics
- Biochemistry
Background
- Clear cell renal cell carcinoma (ccRCC) incidence is rising.
- Bile acid (BA) metabolism is implicated in ccRCC development.
- BA metabolic profiles and biomarker potential in ccRCC are not well understood.
Purpose Of The Study
- To characterize serum BA profiles in ccRCC patients.
- To identify potential BA biomarkers for ccRCC pathogenesis.
- To investigate the relationship between BA profiles and tumor characteristics.
Main Methods
- Serum BA profiles were analyzed in 68 ccRCC patients and 63 controls using UPLC-MS/MS.
- OPLS-DA and ROC analyses were employed to differentiate groups and identify biomarkers.
- Associations between BA profiles and tumor heterogeneity parameters were examined.
Main Results
- ccRCC patients exhibited significantly altered serum BA profiles compared to controls.
- Primary and secondary unconjugated BAs were elevated in ccRCC.
- Deoxycholic acid (DCA) correlated with pTNM stage and grade; CDCA and LCA showed potential as biomarkers.
Conclusions
- Serum BA profiles are altered in ccRCC patients.
- DCA is associated with ccRCC pathological classification and grade.
- CDCA and LCA demonstrate potential as biomarkers for ccRCC pathogenesis.
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