Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.4K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.4K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

486
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
486
Imbalances in Cardiac Output01:23

Imbalances in Cardiac Output

1.2K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to...
1.2K
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

1.8K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
1.8K
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

852
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
852
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

1.6K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Coumarin- and Phthalide-Rich Fraction From Baichuan Baile Formula Alleviates Reserpine-Induced Depression-Like Behaviors by Modulating the Monoaminergic System and Gut Microbiota.

Chemistry & biodiversity·2026
Same author

Evaluation of Therapeutic Effects and Underlying Mechanisms of Baichuan Baile Formula in Rodent Insomnia Models.

Nutrients·2026
Same author

The Novel Soluble Guanylate Cyclase Stimulator Attenuates Acute Lung Injury via Inhibiting Pericyte Phenotypic Transition.

International journal of molecular sciences·2026
Same author

A Polysaccharide-Rich Ingredient from <i>Hypericum perforatum</i> L. Ameliorates Depression-like and Post-Traumatic Stress Disorder-like Symptoms in Mouse Models.

Nutrients·2025
Same author

Baichuan Baile Formula, a Promising Herbal Dietary Supplement, Exerts Antidepressant-Like Effects by Modulating the Serotoninergic System in Mouse Models.

Food science & nutrition·2025
Same author

Urolithin A Exhibits Antidepressant-like Effects by Modulating the AMPK/CREB/BDNF Pathway.

Nutrients·2025

Related Experiment Video

Updated: May 10, 2025

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.1K

Potential mechanisms underlying pathological fatigue-induced cardiac dysfunction.

Hanying Li1,2, Rui Xue2, Yaqian Di2

  • 1Nanjing University of Chinese Medicine, Nanjing, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|April 24, 2025
PubMed
Summary
This summary is machine-generated.

Pathological fatigue impairs heart function. This study developed a novel animal model, revealing hypometabolism and gut microbiota changes as key mechanisms in fatigue-induced cardiac dysfunction.

Keywords:
energy metabolismfatiguegastrointestinal microbiomeshort chain fatty acidsventricular dysfunction

More Related Videos

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

9.9K
Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

11.6K

Related Experiment Videos

Last Updated: May 10, 2025

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.1K
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

9.9K
Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

11.6K

Area of Science:

  • Cardiology
  • Metabolomics
  • Microbiome research

Background:

  • Pathological fatigue is linked to cardiac dysfunction, but models and mechanisms are poorly understood.
  • Existing research lacks suitable animal models to investigate fatigue-induced heart problems.

Purpose of the Study:

  • Establish a novel animal model for pathological fatigue-induced cardiac dysfunction.
  • Investigate the underlying mechanisms, focusing on metabolic and gut microbiota alterations.

Main Methods:

  • Induce pathological fatigue using a 5-week combined stress protocol in an animal model.
  • Assess cardiac function through ejection fraction (EF) and fractional shortening (FS) measurements.
  • Analyze cardiac metabolites using targeted metabolomics and examine gut microbiota composition.

Main Results:

  • The combined stress model successfully induced fatigue phenotypes and cardiac dysfunction, evidenced by reduced EF/FS and elevated myocardial injury biomarkers.
  • Metabolomic analysis revealed a hypometabolic cardiac profile with downregulated fatty acid metabolites, including bacterial products acetate and butyrate.
  • Significant gut microbiota dysbiosis was observed, with specific bacterial genera correlating with altered acetate and butyrate levels and cardiac injury markers.

Conclusions:

  • A novel animal model for pathological fatigue-induced cardiac dysfunction has been established.
  • Hypometabolic features and gut microbiota dysbiosis are identified as critical mechanisms contributing to cardiac dysfunction in pathological fatigue.
  • This study provides insights into the complex interplay between fatigue, metabolism, and the gut microbiome in cardiovascular health.