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Updated: Jun 23, 2026
Synthesis and Characterization of Functionalized Metal-organic Frameworks
Published on: September 5, 2014
Metal-Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy
Qilu Wu1, Yuxiao Feng1, Mathilde Lepoitevin2
1Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, P. R. China.
Insights
Metal-organic frameworks (MOFs) show promise for diagnosing and treating cardiovascular diseases (CVD). This review explores MOFs
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Cardiovascular disease (CVD) is a leading global cause of mortality.
- Early detection and effective treatment are crucial for patient recovery.
- Metal-organic frameworks (MOFs) possess unique properties like high porosity and tunable structures.
Purpose of the Study:
- To review the applications of MOFs in the theranostics of cardiovascular diseases (CVD).
- To explore MOFs' roles in CVD diagnosis (biomarker detection, imaging) and therapy (drug/gas delivery).
- To discuss MOF toxicity and biocompatibility for clinical translation.
Main Methods:
- Literature review of recent advancements in MOF applications for CVD.
- Analysis of MOF properties relevant to biomedical theranostics.
- Synthesis of information on MOF-based diagnostic and therapeutic strategies.
Main Results:
- MOFs are versatile materials for CVD biomarker detection and imaging.
- MOFs serve as effective platforms for targeted drug delivery and therapeutic gas release.
- MOF toxicity and biocompatibility require careful consideration for safe application.
Conclusions:
- MOFs offer significant potential for the integrated diagnosis and treatment of CVD.
- Further research into MOF safety and efficacy will accelerate their clinical adoption.
- MOFs are emerging as key nanomedicine tools for advancing cardiovascular disease theranostics.
Abstract:
Cardiovascular disease (CVD) is one of the most critical diseases which is the predominant cause of death in the world. Early screening and diagnosis of the disease and effective treatment after diagnosis play an important role in the patient's recovery. Metal-organic frameworks (MOFs), a kind of hybrid ordered micro or meso-porous materials, constructed by metal nodes or clusters with organic ligands, due to their special features like high porosity and specific surface area, open metal sites, or ligand tunability, are widely used in various areas including gas storage, catalysis, sensors, biomedicine. Recently, advances in MOFs are bringing new developments and opportunities for the healthcare industry including the theranostic of CVD. In this review, the applications of MOFs are illustrated in the diagnosis and therapy of CVD, including biomarker detection, imaging, drug delivery systems, therapeutic gas delivery platforms, and nanomedicine. Also, the toxicity and biocompatibility of MOFs are discussed. By providing a comprehensive summary of the role played by MOFs in the diagnosis and treatment of CVDs, it is hoped to promote the future applications of MOFs in disease theranostics, especially in CVDs.
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