Identifying the role of Phytomolecules in  the management of liver diseases by modulating NRF2 pathway: A Scoping

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Ajay Mili1, Priyobrat Rajkhowa2, Krishnadas Nandakumar3

  • 1Pharmacognosy, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

F1000Research
|April 24, 2025
PubMed
Abstract

Insights

This review explores how plant-derived compounds (phytomolecules) can protect the liver by activating the NRF2 pathway. Understanding these interactions is key to developing new treatments for liver diseases.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Hepatology

Background:

  • The liver is vital, but susceptible to oxidative stress, a key factor in liver disease pathogenesis.
  • The Nuclear Factor erythroid 2-related factor 2 (NRF2) pathway is crucial for cellular defense against oxidative stress and inflammation.
  • Phytomolecules possess antioxidant properties, but their specific mechanisms in modulating NRF2 for liver protection are not fully understood.

Purpose of the Study:

  • To conduct a scoping review identifying and analyzing literature on phytomolecules that modulate the NRF2 pathway.
  • To elucidate the relationship between phytomolecule-NRF2 interactions and protection against liver diseases.

Main Methods:

  • The review will follow the Arksey and O'Malley and Levac et al. methodological framework.
  • Literature searches will be performed on electronic databases like PubMed/MEDLINE and Embase.
  • Study inclusion/exclusion criteria will be applied by two independent reviewers, adhering to PRISMA-ScR guidelines.

Main Results:

  • Expected to identify key phytomolecules and their mechanisms of action.
  • Will map the current research landscape on NRF2 modulation by phytomolecules in liver health.
  • Will highlight gaps in the existing literature.

Conclusions:

  • Findings will enhance understanding of phytomolecule roles in NRF2-mediated liver protection.
  • This review serves as a basis for developing targeted interventions for liver disease.
  • Aims to contribute to improved liver health outcomes and reduced global disease burden.
Keywords:
Liver diseasesNRF2 pathwayOxidative stressPhytomolecules

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