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Chlorpromazine--a specific effect on breathlessness?

P A O'Neill, P B Morton, R D Stark

    British Journal of Clinical Pharmacology
    |June 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    Promethazine did not alleviate breathlessness in healthy subjects during exercise. Unexpectedly, chlorpromazine significantly reduced breathlessness, suggesting a potential role beyond histamine antagonism for phenothiazines.

    Area of Science:

    • Pharmacology
    • Respiratory Physiology

    Background:

    • Unresolved questions exist regarding promethazine's efficacy in reducing the sensation of breathlessness.
    • Understanding the pharmacological mechanisms underlying breathlessness perception is crucial for developing effective treatments.

    Purpose of the Study:

    • To definitively determine if promethazine reduces breathlessness sensation.
    • To investigate the contribution of promethazine's pharmacological actions, particularly histamine antagonism, to its effect on breathlessness.
    • To compare promethazine's effects with those of chlorpromazine.

    Main Methods:

    • Double-blind, within-subject comparison of promethazine and placebo in 12 healthy subjects.
    • Breathlessness assessed using visual analogue scales during progressive exercise testing.

    Related Experiment Videos

  • Relationship between breathlessness and minute ventilation analyzed.
  • Histamine-antagonism investigated using mebhydrolin in a subgroup.

    • Main Results:

    • Promethazine demonstrated no significant effect on breathlessness or its relationship with ventilation.
    • Mebhydrolin, used to probe histamine antagonism, also showed no effect on breathlessness.
    • Chlorpromazine significantly reduced breathlessness without impacting ventilation or causing sedation.

    Conclusions:

    • Promethazine does not appear to reduce breathlessness sensation in healthy individuals.
    • Histamine antagonism is unlikely to be the primary mechanism by which promethazine might affect breathlessness.
    • Chlorpromazine's potent breathlessness-reducing effect warrants further investigation, especially in patient populations and in the context of its use in palliative care formulations.