Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ranitidine does not alter pethidine disposition in man.

D R Guay, R C Meatherall, J L Chalmers

    British Journal of Clinical Pharmacology
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparison of salivary and serum enzyme immunoassays for the diagnosis of Helicobacter pylori infection.

    The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses·2012
    Same author

    Effects of supplemental dietary tannins on the performance of white-tailed deer (Odocoileus virginianus).

    Journal of animal physiology and animal nutrition·2009
    Same author

    Performance and dietary preferences of white-tailed deer grazing chicory, birdsfoot trefoil or alfalfa in north central Alberta.

    Journal of animal physiology and animal nutrition·2009
    Same author

    Extraction of condensed tannins from cervid feed and feces and quantification using a radial diffusion assay.

    Journal of chemical ecology·2005
    Same author

    Review of cefditoren, an advanced-generation, broad-spectrum oral cephalosporin.

    Clinical therapeutics·2002
    Same author

    Pharmacokinetics of sufentanil in patients undergoing coronary artery bypass graft surgery.

    Journal of cardiothoracic and vascular anesthesia·2001

    Ranitidine does not significantly affect how the body processes pethidine (a pain medication). This study found no pharmacokinetic interactions, suggesting ranitidine may be a safer alternative to cimetidine for patients on pethidine.

    Area of Science:

    • Pharmacokinetics
    • Drug Interactions
    • Clinical Pharmacology

    Background:

    • Concurrent administration of medications can alter drug disposition.
    • Cimetidine is known to interact with pethidine, necessitating investigation into other H2-receptor antagonists.

    Purpose of the Study:

    • To investigate the pharmacokinetic interaction between ranitidine and pethidine in healthy volunteers.
    • To compare the potential for drug interaction between ranitidine and pethidine versus cimetidine and pethidine.

    Main Methods:

    • Eight healthy male volunteers received intravenous pethidine HCl before and during oral ranitidine treatment.
    • Pharmacokinetic parameters including elimination rate, volume of distribution, clearance, and metabolite formation were assessed.

    Related Experiment Videos

    Main Results:

    • Ranitidine administration did not result in significant changes in pethidine's elimination rate constant, volume of distribution, or total body clearance.
    • No significant alterations were observed in the oxidation of pethidine to norpethidine, indicating no pharmacokinetic interaction.

    Conclusions:

    • Ranitidine does not appear to interact pharmacokinetically with pethidine.
    • Unlike cimetidine, ranitidine may offer a safer alternative for patients requiring concurrent pethidine therapy.