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Updated: May 10, 2025

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

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Published on: March 14, 2011

Aortitis triggered by granulocyte-colony stimulating factor.

Andreas Gaustad¹, Marthe Halsan Liff², Aleksander Nordberg Nørgaard³

¹Medisinsk avdeling, Diakonhjemmet sykehus, Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke

|April 24, 2025

Summary

This summary is machine-generated.

Granulocyte-colony stimulating factor (G-CSF) can cause aortitis in lymphoma patients, presenting as fever and elevated CRP. Discontinuing G-CSF and using imaging are key for diagnosis and treatment.

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Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

Area of Science:

Oncology
Vascular Medicine
Pharmacology

Background:

A sixty-year-old male diagnosed with diffuse large B-cell lymphoma.
Patient presented with fever, myalgia, and lethargy post-chemotherapy with G-CSF.

Purpose of the Study:

To report a rare case of G-CSF-induced aortitis.
To highlight diagnostic considerations for fever post-G-CSF therapy.

Main Methods:

Clinical case presentation.
Laboratory investigations including C-reactive protein (CRP) monitoring.
Computer tomography (CT) scan for imaging.

Main Results:

Patient developed fever and elevated CRP despite antibiotic treatment.
CT scan revealed aortitis, suspected to be G-CSF induced.
Discontinuation of G-CSF and initiation of prednisolone led to rapid improvement.

Conclusions:

G-CSF-induced aortitis is a potential diagnosis in patients with fever post-G-CSF treatment unresponsive to antibiotics.
Advanced imaging is crucial for diagnosis.
Prompt discontinuation of G-CSF is the primary management strategy.