Results of the Precision Event Monitoring for Patients With Heart Failure Using HeartLogic Study (PREEMPT-HF)

Area of Science:

• Cardiology
• Medical Devices
• Remote Patient Monitoring

Background:

• Heart failure (HF) hospitalizations necessitate improved post-discharge monitoring to reduce readmissions.
• Current management strategies require enhancement for effective HF patient care.

Purpose of the Study:

• To investigate the association between remote monitoring data and heart failure readmissions.
• To evaluate the predictive value of the HeartLogic index for HF patient outcomes.

Main Methods:

• The PRecision Event Monitoring for PatienTs with Heart Failure using HeartLogic (PREEMPT-HF) study enrolled 2,155 adult HF patients.
• Patients were remotely monitored using HeartLogic-capable implantable cardioverter-defibrillator and cardiac resynchronization therapy devices.
• Clinicians and patients were blinded to alerts, with a 12-month follow-up for event reporting.

Main Results:

• The study observed 243 HF hospitalizations and 45 all-cause readmissions within 90 days.
• HeartLogic alert sensitivity was 78.3% for outpatient visits and HF hospitalizations, with a 1.18/year false-positive rate.
• A higher HeartLogic index before or after index HF hospitalizations correlated with subsequent HF or all-cause readmissions.

Conclusions:

• HeartLogic index trends differed significantly in patients readmitted for HF.
• These findings suggest that sustained worsening or inadequate intervention during initial HF hospitalization predicts readmission risk.
• Remote monitoring with HeartLogic offers potential for proactive HF management and readmission reduction.