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Association of Decreased Fecal Microbiota Akkermansia with Increased High-Sensitivity C-Reactive Protein Levels in
Yuan-Fan Yuan1,2,3, Ji-Yu Zhang1,2,3, Jia-Hao Xu1,2,3
1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Insights
Reduced Akkermansia in the gut microbiota is linked to higher inflammation risk in unstable angina patients. This suggests a connection between gut health and cardiovascular inflammation, warranting further investigation.
Area of Science:
- Cardiovascular Medicine
- Microbiome Research
- Inflammation Biology
Background:
- Coronary artery disease (CAD) progression is significantly influenced by inflammation.
- High-sensitivity C-reactive protein (hsCRP) is a key biomarker for cardiovascular inflammation risk.
- The specific gut microbiota alterations contributing to elevated inflammation in CAD remain largely unknown.
Purpose of the Study:
- To investigate the correlation between gut microbiota composition and inflammation levels in patients with unstable angina (UA).
- To identify specific microbial changes associated with elevated hsCRP, a marker of inflammation, in UA patients.
Main Methods:
- Fecal samples and plasma hsCRP levels were analyzed from 92 unstable angina patients.
- 16S rRNA sequencing was used to profile the fecal microbial composition.
- Patients were grouped based on median hsCRP levels to compare microbiota profiles and analyze correlations.
Main Results:
- A significant reduction in the relative abundance of Akkermansia was observed in patients with higher hsCRP levels (≥ 1.11 mg/L).
- No significant differences in overall fecal microbiota diversity were found between high and low hsCRP groups.
- Akkermansia abundance showed a negative correlation with hsCRP levels.
Conclusions:
- Decreased Akkermansia levels are significantly associated with increased inflammatory risk in unstable angina patients.
- These findings highlight the potential role of the gut microbiota in mediating inflammation within the context of UA.
- Further research is necessary to elucidate the precise mechanisms through which the gut microbiota influences inflammatory risk in UA.
Background And Objective:
Inflammation plays a pivotal role in the progression of coronary artery disease (CAD). High-sensitivity C-reactive protein (hsCRP) serves as a well-established biomarker for assessing cardiovascular inflammation risk. However, the specific intestinal microbiota alteration contributing to increased inflammation remains unclear. Therefore, the present study investigated the correlation between the intestinal microbiota and inflammation in patients with unstable angina (UA).
Methods:
A cohort of 92 patients with UA was recruited for this study. The plasma hsCRP level was measured via a CardioPhase hsCRP assay, fecal samples were collected after admission, and 16S rRNA sequencing was conducted to identify the fecal microbial profile. The participants were classified into two groups according to the median hsCRP level (1.11 mg/L). The composition of the fecal microbiota was compared between patients with hsCRP ≥ 1.11 mg/L and those with hsCRP < 1.11 mg/L. Additionally, the correlations between the fecal microbiota and clinical characteristics were analyzed.
Results:
A notable reduction in the relative abundance of Akkermansia was observed in patients with hsCRP ≥ 1.11 mg/L, whereas the diversity of the fecal microbiota was not significantly different between patients with hsCRP ≥ 1.11 mg/L and those with hsCRP < 1.11 mg/L. Furthermore, the abundance of Akkermansia was negatively correlated with hsCRP levels.
Conclusion:
This study suggested a significant association between decreased levels of Akkermansia and inflammatory risk in patients with UA. These findings underscore the potential role of the intestinal microbiota in contributing to inflammation in UA patients. Further work is needed on the mechanism by which the microbiota contributes to inflammatory risk.
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