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Photoreceptors and Visual Pathways

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...

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Related Experiment Video

Updated: May 10, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

Cone Density Changes After Repeated Low-Level Red Light Treatment in Children With Myopia.

Xinyi Liao^1,2,3, Jifeng Yu⁴, Yuzhuo Fan^1,2,3,5

¹Department of Ophthalmology, Peking University People's Hospital, Beijing, China.

JAMA Ophthalmology

|April 24, 2025

Summary

Repeated low-level red light (RLRL) therapy for myopia control in children may reduce cone density in the paracentral fovea. Further research is needed to assess the long-term safety of this therapy.

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Last Updated: May 10, 2025

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Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients

Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients

Published on: March 29, 2022

Area of Science:

Ophthalmology
Retinal imaging
Pediatric optometry

Background:

Repeated low-level red light (RLRL) therapy is explored for myopia control in children.
Long-term effects of RLRL therapy on retinal photoreceptors are not well understood.

Purpose of the Study:

To evaluate changes in cone photoreceptor density in children with myopia undergoing RLRL therapy.
Utilizing high-resolution adaptive optics scanning laser ophthalmoscopy (AOSLO) to assess retinal changes.

Main Methods:

Retrospective multicenter cohort study of Chinese children (5-14 years) with myopia.
Cone density measured using AOSLO along retinal meridians.
Comparison between RLRL therapy group and control group.

Main Results:

RLRL therapy associated with decreased cone density near the foveal center, particularly in the temporal region.
Increased odds of abnormal low-frequency, high-brightness signals in RLRL users.
One case of transient cystoid abnormalities on OCT in the ganglion cell layer.

Conclusions:

RLRL therapy for myopia control may lead to reduced cone density and subtle retinal abnormalities.
Findings highlight the need for further investigation into the long-term safety of RLRL therapy in pediatric myopia management.