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[Effect of the antiseptic merthiolate and its derivatives on fungi causing deterioration]
Abstract:
The fungistatic activity of merthiolate and its two polymerous derivatives have been investigated using as test cultures fungi producing deterioration. The fungicides sorbtion dynamics by the fungus micelium have been studied, toxicity and inhibition rate of the catalase from different sources have been evaluated. The polymerous derivatives have been found to maintain high fungistatic activity of merthiolate, but possess less toxicity. The sorbtion of the polymerous derivative by the fungal mycelium takes place more effectively than the merthiolate sorbtion. The probable reasons of the high activity of the merthiolate polymerous derivatives are under discussion.
Insights
New polymer derivatives of merthiolate show strong fungistatic activity with reduced toxicity. These compounds are more effectively absorbed by fungal mycelium, offering potential for improved antifungal applications.
Area of Science:
- Mycology
- Biochemistry
- Polymer Science
Context:
- Fungal deterioration poses significant challenges in various industries.
- Merthiolate is a known fungicide, but its toxicity is a concern.
- Development of safer and more effective antifungal agents is crucial.
Purpose:
- To investigate the fungistatic activity of merthiolate and its novel polymer derivatives.
- To compare the sorption dynamics and toxicity of these compounds by fungal mycelium.
- To evaluate the inhibition rate of catalase by merthiolate and its derivatives.
Summary:
- The study evaluated the fungistatic properties of merthiolate and two polymer derivatives against fungi causing deterioration.
- Sorption dynamics by fungal mycelium, catalase inhibition, and toxicity were assessed.
- Polymer derivatives retained high fungistatic activity while exhibiting lower toxicity and enhanced sorption compared to merthiolate.
Impact:
- The findings suggest that merthiolate polymer derivatives are promising candidates for developing less toxic and more effective antifungal agents.
- Enhanced understanding of the interaction between polymer fungicides and fungal cells.
- Potential for new applications in material preservation and agriculture.