Related Experiment Video For Marjolin ulcer
Updated: May 10, 2025
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Squamous cell carcinoma arising from chronic enteroatmospheric fistula
Phillip Alix1, Genesis Moseley, Shai Chazin
1Phillip Alix was a student in the PA program at South University in Tampa, Fla., at the time this article was written, and now practices at Pareto Population Health Management in Jacksonville, Fla. Genesis Moseley practices in the Division of Advanced Gastrointestinal and Bariatric Surgery at Mayo Clinic in Jacksonville, Fla. Shai Chazin is a general surgery resident at Mayo Clinic in Jacksonville, Fla. Courtland Polley was a gastrointestinal surgery fellow at Mayo Clinic in Jacksonville, Fla., at the time this article was written, and is now a general surgeon at North Florida Surgeons in Jacksonville, Fla. Steven Bowers is a consultant physician and professor of surgery in the Division of Colon and Rectal Surgery at Mayo Clinic in Jacksonville, Fla. Amanda P. Stanton practices in the Department of Gastroenterology at Mayo Clinic in Jacksonville, Fla. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Abstract:
Marjolin ulcers are aggressive, cutaneous malignancies typically arising from chronic, nonhealing wounds. The presence of an obvious defect often masks this potentially life-threatening condition, making detection difficult and frequently leading to delayed diagnosis. Most cases of Marjolin ulcers are squamous cell carcinoma (SCC) in histology. Unlike for other common cutaneous malignancies, no clear guidelines or protocols are in place for early surveillance and management of Marjolin ulcers. Given the aggressive nature of this malignancy when associated with metastasis, early diagnosis and intervention are imperative. We present a unique case describing an immunocompromised patient with an extensive surgical abdominal history who had developed a cutaneous mass determined to be well-differentiated invasive SCC on final histology. The mass was superimposed over a chronic enteroatmospheric fistula that was present for more than 20 years.
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