Preferential uptake of intravenously administered hyaluronidase (Hyalosidase) by damaged rat myocardium

Area of Science:

• Cardiology
• Biochemistry
• Pharmacology

Background:

• Myocardial infarction (MI) is a leading cause of death worldwide.
• Accurate diagnosis and targeted therapy for MI remain critical challenges.

Purpose of the Study:

• To establish a rat model of myocardial infarction.
• To investigate the biodistribution of 125I-labelled hyaluronidase in this model.

Main Methods:

• Myocardial infarction was induced in rats by left-anterior coronary artery ligation.
• Plasma levels of creatine kinase, aspartate aminotransferase, and lactate dehydrogenase were measured to confirm MI.
• 125I-labelled hyaluronidase was administered intravenously, and its uptake in damaged and normal myocardium was assessed.

Main Results:

• Successful induction of myocardial infarction was confirmed by elevated cardiac enzyme levels.
• Intravenous administration of 125I-labelled hyaluronidase resulted in significantly higher uptake in the damaged myocardium compared to normal heart tissue.

Conclusions:

• The established rat model reliably replicates key features of human myocardial infarction.
• 125I-labelled hyaluronidase demonstrates preferential accumulation in infarcted cardiac tissue, suggesting potential as a diagnostic or therapeutic agent.