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Updated: May 14, 2025
Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons
Published on: February 5, 2015
Assessing the neurotoxic risks of triethyl citrate in daily environmental exposure using network toxicology and
Wenhao Ouyang1, Chenjie Zhu2, Yudi Li1
1Department of Neurology, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, China.
Abstract:
Synthetic chemicals like triethyl citrate (TEC) are widely used in food packaging, pharmaceuticals, and cosmetics. Despite being considered safe, there are concerns about TEC's potential neurotoxic effects. In this study, we used network toxicology and molecular docking to examine TEC's impact on the nervous system. We identified 229 targets related to neurotoxicity and found that TEC may affect key processes such as cell death, inflammation, and neuronal health. Molecular docking showed strong interactions between TEC and proteins like MAPK3, SRC, CASP3, TNF, and BCL2, suggesting a risk of neural damage and the need for further research to assess TEC's safety.
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