[Temporal organization of the cellular reproduction processes in Ehrlich ascites tumor]

Experiments were made on randombred male mice weighing 18-20 g maintained on the light regimen L:D-12:12. The animals were given a single injection i. p. of a hypotetraploid subline of Ehrlich's ascites tumor. Fluctuations in the number of mitotic cells and no changes in the number of DNA-synthesizing cells were established. This indicates that synchronization of tumor cells under these conditions occurs mainly in the G2 phase. The results of the present experiments confirm those obtained during previous investigations, showing the lack of the dependence of the cell proliferation pattern on the cell ploidy. The disturbance of the chronobiological organization of tumor cell proliferation that is manifested by upset synchronization of cell division and DNA synthesis is common to all Ehrlich's ascites tumor sublines under study.