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Research Progress and Future Opportunities for Pediatric Cow Milk Protein Allergy: A Bibliometric Overview and
Li Zhou1, Tengfei Li2,3, Qingyong Zheng3
1Department of Pediatric Gastroenterology, Gansu Province Maternity and Child Health Hospital, Gansu Province Central Hospital, Lanzhou, China.
Insights
This bibliometric study analyzes pediatric cow milk protein allergy (CMPA) research, identifying key trends and emerging topics like the gut microbiome and dairy substitutes. Future collaboration is encouraged for better CMPA management.
Area of Science:
- Pediatric Allergy and Immunology
- Bibliometrics
- Food Hypersensitivity
Background:
- Cow milk protein allergy (CMPA) is a significant concern in pediatric health.
- Understanding research trends is crucial for advancing CMPA diagnosis and treatment.
Purpose of the Study:
- To conduct a bibliometric analysis of research on CMPA in children.
- To identify key research trends, influential publications, and emerging hotspots in the field.
Main Methods:
- Bibliometric analysis of 1,128 articles from the Web of Science Core Collection.
- Utilized VOSviewer and Biblioshiny for network analysis, keyword co-occurrence, and thematic mapping.
Main Results:
- Research on pediatric CMPA has increased since 2014, with the US, Italy, and China as leading contributors.
- Key research areas include clinical aspects, molecular mechanisms, immune regulation, and immunotherapy.
- Emerging hotspots include the gut microbiome, dairy substitutes, and sELISA technology.
Conclusions:
- Bibliometric analysis reveals significant trends and hotspots in pediatric CMPA research.
- International collaboration should be enhanced to advance CMPA research and management.
Introduction:
This study employs bibliometric methods to reveal research trends, hot topics, and development trajectories in the field of cow milk protein allergy (CMPA) in children.
Methods:
We retrieved and downloaded literature on CMPA in children from the Web of Science Core Collection database on the basis of specific search strategies and screening criteria. Using VOSviewer software, we analyzed the collaboration networks among countries, institutions, and authors, as well as the co-occurrence of keywords. We utilized Biblioshiny software to analyze highly cited papers and research trend topics and to construct thematic maps.
Results:
We included 1,128 articles related to pediatric CMPA for analysis. The results show that since 2014, the number of research papers on CMPA has increased. The USA, Italy, and China are the countries with the greatest number of publications, with the USA occupying a central position in the collaboration network. The Icahn School of Medicine at Mount Sinai ranks first in terms of research output. Professor Hugh A. Sampson is the most influential author in this field. The main research areas include clinical manifestations, molecular mechanisms, immune regulation, and immunotherapy for CMPA. Emerging research hotspots in recent years include the gut microbiome, the development of dairy substitutes, and the application of sandwich enzyme-linked immunosorbent assay (sELISA) technology in milk protein detection.
Conclusion:
Through bibliometric analysis, this study revealed the research trends and hotspots in the field of CMPA in children. Future research should further strengthen international cooperation to promote in-depth research and effective management of CMPA.
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