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Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
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Unexpected enzymatic function of an ancient nucleic acid-binding fold.

Rylan R Watkins1, Stella Bockelman1, Anna Vradi1

  • 1Department of Chemistry and Biochemistry, Center for RNA Biology, Ohio State University, Columbus, OH, 43220, United States.

Nucleic Acids Research
|April 24, 2025
PubMed
Summary

Trypanosoma brucei MCP1, a protein with an OB-fold, unexpectedly deacylates Ala-tRNAs, ensuring translation fidelity. This conserved function highlights an ancient nucleic acid binding domain

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