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Natural product-based nanotechnological formulations for colorectal cancer treatment
Lanfang Wu1, Jiali Wu1, Xinyu Wang2
1Fujian University of Traditional Chinese Medicine, No. 1 Qiuyang Road, Fuzhou, 350122, China.
Abstract:
Colorectal cancer is one of the most common malignancies affecting the gastrointestinal tract. A silent onset often marks it and carries a poor prognosis. Studies have shown that natural products can suppress the growth of colorectal cancer and exert therapeutic effects at the molecular level. However, unfavorable physicochemical properties frequently hinder their clinical application, such as low solubility, limited bioavailability, short half-life, and rapid systemic clearance. As scientific and technological progress continues, increasing attention has been directed toward nanotechnology-based approaches. Techniques involving nanoparticles, liposomes, and micelles are being explored to improve drug delivery. These advancements provide a promising foundation for overcoming the limitations associated with natural products. This review systematically examines the application of nano-formulations for natural ingredients to offer meaningful insights into their. potential use in treating colorectal cancer.
Insights
Natural products show promise for colorectal cancer treatment but face delivery challenges. Nanotechnology offers solutions by improving the properties of these natural compounds for better therapeutic outcomes.
Area of Science:
- Oncology
- Nanotechnology
- Pharmacology
Background:
- Colorectal cancer is a prevalent gastrointestinal malignancy with often poor prognosis due to silent onset.
- Natural products demonstrate potential in suppressing colorectal cancer growth and offering molecular-level therapeutic effects.
- Limitations of natural products include poor solubility, bioavailability, short half-life, and rapid clearance, hindering clinical use.
Purpose of the Study:
- To review the application of nano-formulations for natural ingredients in colorectal cancer treatment.
- To explore how nanotechnology can overcome the delivery limitations of natural products.
- To provide insights into the potential of nano-formulated natural products for colorectal cancer therapy.
Main Methods:
- Systematic review of scientific literature.
- Examination of nanotechnology-based approaches (nanoparticles, liposomes, micelles).
- Analysis of studies on nano-formulations of natural products for colorectal cancer.
Main Results:
- Nanotechnology significantly improves the physicochemical properties of natural products.
- Nano-formulations enhance drug delivery, bioavailability, and therapeutic efficacy.
- Various nano-delivery systems show promise in preclinical colorectal cancer models.
Conclusions:
- Nano-formulations represent a promising strategy to overcome the limitations of natural products for colorectal cancer treatment.
- Nanotechnology-based drug delivery systems can enhance the clinical application of natural compounds.
- Further research into nano-formulated natural products could lead to novel colorectal cancer therapies.
