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Updated: May 6, 2026
RNA-seq Analysis of Transcriptomes in Thrombin-treated and Control Human Pulmonary Microvascular Endothelial Cells
Published on: February 13, 2013
Automated, open-source, vendor-independent quality assurance protocol based on the Pulseq framework
Qingping Chen1, Niklas Wehkamp2, Cai Wan2,3
1Division of Medical Physics, Department of Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. qingping.chen@uniklinik-freiburg.de.
Objectives:
Consistent image quality and signal stability are crucial for neuroimaging, particularly fMRI studies that rely on detecting small BOLD signal changes. Regular MR system performance monitoring is essential, especially for longitudinal and multi-site studies. This work aims to establish a robust quality assurance (QA) protocol to enhance data comparability across days, scanner versions, vendors, and sites.
Materials And Methods:
We implemented an open-source, vendor-independent QA protocol using Pulseq for standardized data acquisition and ISMRMRD/Gadgetron for harmonized image reconstruction, accompanied by an automated post-processing pipeline to evaluate structural and temporal image quality. The protocol was thoroughly tested on three Siemens 3T scanners with different software versions at one site, and one GE 3T scanner at another site. The test was repeated on an fBIRN phantom for at least 4 days.
Results:
The vendor-independent protocol produced image quality comparable to a closely matched vendor-based protocol. It showed similar day-to-day repeatability to the vendor-based protocol across the Siemens scanners and high inter-day repeatability on the GE scanner.
Conclusion:
We successfully developed and implemented an open-source, vendor-independent QA protocol, accompanied by an automated post-processing pipeline. The results demonstrate the feasibility and repeatability of the protocol across different days, system versions, vendors, and sites.
