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Updated: May 10, 2025

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
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Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins

Sandra Zakrzewska1, Samantha A Nixon1, Zhou Chen1,2

  • 1Cardiovascular Research Institute, University of California, San Francisco, CA, USA.

Nature Communications
|April 24, 2025
PubMed
Summary

Saxiphilins (Sxphs) act as toxin sponges, binding saxitoxin (STX) and its variants. These proteins reverse STX-induced sodium channel (NaV) blockage, aiding in toxin detection and mitigation strategies.

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