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Updated: Aug 6, 2026

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
Published on: November 17, 2011
New dimeric 5-hydroxy-2-hexenoic acid isolated from culture broth of Clonostachys rogersoniana
Dae-Cheol Choi1, Dae-Won Ki1, Yoon Hee Kim2
1Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Gobong-ro 79, Iksan, 54596, Korea.
Abstract:
A new dimeric 5-hydroxy-2-hexenoic acid, clonohexenoic acid (1), a known 14-membered macrolide, acremodiol B (2), and two known benzochromenone derivatives, alternariol (3) and 2-hydroxyalternariol (4), were isolated from a culture broth of Clonostachys rogersoniana. The structures of these isolated compounds were determined using spectroscopic methods. Antimicrobial and cytotoxic activities of these compounds were then assessed. Compounds 1‒4 exhibited antimicrobial activities against Bacillus subtilis and Propionibacterium acnes. In addition, compounds 3 and 4 showed antibacterial activities against B. cereus and cytotoxic activities against three human cancer cell lines, A549, HCT-116, and Mia Paca-2.
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