Halogen Bonding Promoted Photoinduced Synthesis of 3,3-Disubstituted Oxindoles
Kun-Quan Chen1, Jia Zhang2, Xiao-Bo Chen2
1School of Pharmacy and Medical Technology, Putian University, Key Laboratory of Medical Microecology (Putian University), Putian 351100, China.
Abstract:
A photoinduced and catalyst-free radical cyclization process for the synthesis of 3,3-disubstituted oxindoles is reported. This method utilizes readily available α-bromoanilides as substrates, showcasing a broad substrate scope. The reaction mechanism is facilitated by a photoactivated charge transfer complex based on the halogen bonding of α-bromoanilide with TMG and alcohol.
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