Can Aggressive Papillary Thyroid Carcinoma Variants With Oncocytıc Morphology (Tall Cell and Hobnail Variants) be Detected Cytologically? Is the Differentiation as Straightforward as Reported?
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View abstract on PubMed
Summary
This summary is machine-generated.Identifying aggressive papillary thyroid carcinoma (PTC) variants is crucial for treatment. Cellular swirls, nuclear grooves, and scant-medium cytoplasm are key cytological indicators for distinguishing aggressive PTC during fine-needle aspiration (FNA).
Area Of Science
- Cytopathology
- Endocrine Pathology
- Surgical Oncology
Background
- Accurate identification of aggressive papillary thyroid carcinoma (PTC) variants is vital for appropriate surgical management.
- Oncocytic morphology, characterized by abundant granular cytoplasm due to mitochondrial accumulation, is a feature of certain PTC variants.
- Aggressive variants like tall cell and hobnail PTC exhibit oncocytic features, necessitating early detection.
Purpose Of The Study
- To evaluate cytomorphological features in 51 histologically confirmed PTC cases with oncocytic morphology.
- To identify specific cytological indicators for differentiating aggressive (tall cell, hobnail) from non-aggressive (oncocytic, Warthin-like) PTC variants at the FNA stage.
Main Methods
- Retrospective examination of cytological features from 51 PTC cases with confirmed oncocytic morphology.
- Cases were categorized into poor prognosis (tall cell, hobnail) and good prognosis (oncocytic, Warthin-like) groups.
- Statistical analysis was performed to identify significant cytomorphological differences between the groups.
Main Results
- The poor prognosis group (n=12) showed a significantly higher frequency of cellular swirls (83.3%) compared to the good prognosis group (n=39) (43.6%, p=0.022).
- Nuclear grooves were present in all poor prognosis cases (100%) versus 61.5% of good prognosis cases (p=0.011).
- Scant-medium cytoplasmic volume was more common in the poor prognosis group (66.7% vs. 20.5%, p=0.005), achieving the highest accuracy rate (76.4%).
Conclusions
- Oncocytic morphology-based cytological analysis can aid in identifying poor prognosis PTC variants.
- Cellular swirls, nuclear grooves, and scant-medium cytoplasmic volume are significant cytological indicators for aggressive PTC.
- These findings can guide clinical decisions and enable earlier detection of aggressive PTC variants.
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